Stages In Healing Of Wounds

Stages In Healing Of Wounds

1.) Inflammatory Phase

The first response to injury

1-4 day after injury

Characterized by redness, cancer, pain, heat

Platelet aggregation and activation

Press leukocytes (neutrophils, macrophages), migration, phagocytosis and mediator

Dilation of the veins

Lymphatic blockade

Exudative

Wounds closed primary purpose, it will take 4 days

In wounds closed by secondary intention or tertiary continues until complete epithelialization

2). Proliferative phase

4-42 Day

Fibroblast proliferation stimulated macrophages release growth factors

The increased amount of collagen synthesis in fibroblasts

Granulation tissue and neovascularization

Gains tensile strength

3.) Remodeling Phase

6wks-1 year

Intermolecular cross-linking of collagen through the vitamin C-dependent hydroxylation

Characterized by an increase in tensile strength

Type III collagen type I was replaced

Scar surfaces